Grating-based X-ray Dark-field Computed Tomography of Living Mice
نویسندگان
چکیده
منابع مشابه
Grating-based X-ray Dark-field Computed Tomography of Living Mice
Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary netw...
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Grating-based x-ray imaging provides three principle kinds of contrast: absorption, phase, and dark-field. Due to the availability of tomographic reconstruction algorithms for the dark-field contrast, it is now possible to take advantage of quantitative scatter information. However, the published algorithm is based on several assumptions that might be violated in reality. We use numerical simul...
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Imaging with visible light today uses numerous contrast mechanisms, including bright- and dark-field contrast, phase-contrast schemes and confocal and fluorescence-based methods. X-ray imaging, on the other hand, has only recently seen the development of an analogous variety of contrast modalities. Although X-ray phase-contrast imaging could successfully be implemented at a relatively early sta...
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Phase-contrast x-ray computed tomography (PCCT) is currently investigated as an interesting extension of conventional CT, providing high soft-tissue contrast even if examining weakly absorbing specimen. Until now, the potential for dose reduction was thought to be limited compared to attenuation CT, since meaningful phase retrieval fails for scans with very low photon counts when using the conv...
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ژورنال
عنوان ژورنال: EBioMedicine
سال: 2015
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2015.08.014